4 days old

Sr Data Process Scientist

Patheon
Missouri City, TX 77489
109209BR
Location :
US - Missouri - St. Louis
:
Job Description

Job Title: Sr Data Scientist


When you’re part of the team at Thermo Fisher Scientific, you’ll do important work, like helping customers in finding cures for cancer, protecting the environment or making sure our food is safe. Your work will have real-world impact, and you’ll be supported in achieving your career goals.

Location/Division
St Louis, MO | BioProduction Division


How will you make an impact?
The Senior Data Scientist Automation will be a member of the Bio Collaboration Center (BCC) Team. The Sr Data Scientist is responsible for providing advanced level expertise to global automation projects including feasibility & concept studies, capital facility buildouts and equipment purchases, facility master plans, process improvement (S)he will create and maintain relationships with other Thermofisher network resources to develop and promote engineering best practices and ensures compliance with SOP's, safe work practices, and cGMP regulations. The position involves close collaboration with Manufacturing, Manufacturing Sciences, Quality Assurance, Quality Control, and Global and Site Engineering teams to complete all responsibilities. The preference is that the role be in St. Louis, MO. Global travel expectations up to 20% within multiple sites for Thermo Fisher Scientific

What will you do?
  • The individual will oversee the development of and design, implementation and maintenance for the real time GMP manufacturing process monitoring programs (e.g. SIMCA) for the Thermo Fisher development team.
  • The individual will have specific subject matter expertise in process analytics and working knowledge of distributed control systems, PI historian, Statistica, LIMS, JMP and other multivariate process analytical tools.
  • The individual will have the expertise to identify potential improvement projects utilizing advanced analytics and process knowledge (PAT, QBD, etc). Working in commercial manufacturing facility and GxP experience is required.
  • Previous project management experience implementing similar systems/programs at other biotech or biopharma companies is also required.
  • Strong cross functional collaboration skills are essential.
  • A key part of this role will be leading development phase and the identification of key innovative real-time multivariate and predictive analytics platforms in support of new development platforms for use in clinical and commercial manufacturing unit operations.
  • This will include working with a focus team to define user requirements, models documentation, and other design and implementation documents (e.g. functional specifications, configuration specifications, etc).
  • The Process Analytics Engineer will work with subject matter experts both with in Patheon and Thermo Fisher Scientific, as well as in industry forums to collect and process data for use in creating models, utilizing a variety of automated tools (e.g. VBA, R/Python, etc).
  • They will then define and create models for individual process units, including cell culture and purification operations.
  • The individual will be tasked to test, document, and deploy for real-time use the defined models.
  • The Process Analytics Engineer will work with local MSAT to provide training on the usage and representation of the multivariate models.
  • Expertise in multivariate modeling methods, including PCA/PLS, OPLS, Discriminant analysis, etc.
  • The Sr Data Scientist also has responsibilities to develop tools to support process monitoring, scientific process support, root cause analysis, transition analysis in support of chromatography columns, and projects to improve processing time, productivity, product quality, and a better customer experience.
  • The individual will collaborate with/provide guidance to key subject matter experts (SMEs) from the Manufacturing Sciences floor support team as well as cross functional groups such as Automation Engineering, Digital and Data Sciences, Process Development and Manufacturing.
  • Works with IT and Automation teams to support data collection, data integrity, integration and incorporating business requirements and best practices.
  • Evaluate current processes and identify process improvement opportunities, including development of automated controls and predictive process monitoring.
  • Draws conclusions and effectively communicates findings with both technical and non-technical team members.
  • The individual will be able to assess and design a phased approach in the project plan based on readiness of peripheral systems, design and building of process models and capital/resource availability.

How will you get here?

Education
  • The ideal candidate will have a BS in Chemical/Biochemical Engineering or Bio/Chemistry with 6 -8 years or an MS with 4-6 years of applicable process automation, process analytics, technical support or process/facility design experience.
Experience
  • Experience with process historian/data collection systems and data analysis/reporting applications such as SIMCA, PI Historian, PI Process Book, Excel, JMP and Statistica is a must.
  • A sound technical knowledge of major unit operations associated with biologics manufacturing such as cell culture, recovery, fluid transfer, filtration, chromatography, CIP/SIP, and UF/DF processes is required.
  • Design or operational experience with large-scale cell culture and protein purification for both clinical and commercial processes is also preferred.
  • Experience with executing cGMP facility construction, process equipment, utilities, and automation projects and/or supporting these areas in an operating biomanufacturing facility
  • Working knowledge of cGMP, OSHA, NEC and EPA regulations
  • Experienced in an FDA regulated environment
  • Experience with systems such as OSI PI, Infobatch and AlarmWorX, ESXi, Syncade, Pharmasuite installation and support
  • Understanding in implementing MES functionality related to bio-manufacturing facility
  • Understanding of bridge between typical business / quality IT systems and manufacturing automation systems (ERP, LIMS, QMS, etc)
  • Understanding of P&ID instrumentation and loop tuning fundamentals
  • In depth understanding of general cGMP standards and practices

Knowledge, Skills, Abilities
  • Ability to work effectively with both local and remote teams in a matrix environment
  • Proficient in standard MS tools and software required to execute job requirements (AutoCAD, etc).
  • Strong technical documentation review and revision experience
  • Experience with people and project management
  • Experience with single-use bio-manufacturing technologies and automation strongly desired



At Thermo Fisher Scientific, each one of our 70,000 extraordinary minds has a unique story to tell. Join us and contribute to our singular mission—enabling our customers to make the world healthier, cleaner and safer.

Apply today! http://jobs.thermofisher.com

Thermo Fisher Scientific is an EEO/Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status.




If you are an individual with a disability who requires reasonable accommodation to complete any part of our application process, click here for further assistance.

Thermo Fisher Scientific is an EEO/Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status.

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Posted: 2019-12-03 Expires: 2020-01-02

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Sr Data Process Scientist

Patheon
Missouri City, TX 77489

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