8 days old

Senior Engineer Systems Design-Cell Culture

Patheon
Missouri City, TX 77489
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109208BR
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Job Description

Job Title: Senior Engineer Systems Design-Cell Culture

When you’re part of the team at Thermo Fisher Scientific, you’ll do important work, like helping customers in finding cures for cancer, protecting the environment or making sure our food is safe. Your work will have real-world impact, and you’ll be supported in achieving your career goals.

Location/Division

St Louis, MO | BioProduction Division


How will you make an impact?
  • Drives implementation of Upstream based collaboration projects across both Thermo Fisher and Patheon as a member of the Bioprocessing Collaboration Team (BCC).
  • Acts as technical lead on multiple programs. Investigates, creates, and develops new scientific methodologies on a SUT unit operations in a cross company matrixed team environment.
  • Evaluates and contributes to the discovery, development and innovation of Single Use Technology unit operations and supporting systems (including automation execution).
  • Tests bioreactors, develops harvest technologies, supports continuous processing strategies.
  • Drives early adoption of new SUT’s into both clinical and commercial operations at both PSG internally to Thermo Fisher as well as aids in the launch strategies for new SUT’s at Thermo Fisher.
  • Supports the testing of new technology processes and supports problem solving as necessary with independent judgment.
  • Able to solve complex problems with regards to Cell Culture opportunities in industry (across Thermo Fisher Development and Patheon Operations).
  • Determines methods and procedures including automation support to new assignments and may coordinate activities of other employees and or cross functional business teams.
  • Supports implementation of the following technologies: Analytical benchtop equipment, SUT cell culture systems, Automation application to cell culture control and data trending.
  • Will aid in project management for development of key projects within the Bioprocessing Collaboration Center at St Louis.

What will you do?
  • Leads design of experimental plans based on the defined deliverables.
  • Conducts complex analyses to support testing and development of SUT systems. Works with Process Development and Manufacturing groups to trouble-shoot process challenges.
  • Records results in notebook accurately, clearly, and regularly, and reviews documentation by others.
  • Prepares protocols, reports, and test methods and writes SOPs.
  • Maintains and ensures safe laboratory environment and work practices.
  • Executes appropriately record and evaluate experimental data, including the writing and revising of process development reports and technology transfer protocols as needed.
  • Remains current in the field by review of relevant scientific literature and attendance at appropriate scientific seminars and conferences.
  • Analytical: Leads complex analytical methods and tests on mammalian tissues, sterility tests, growth promotion, microbial limits tests, and/or and antimicrobial effectiveness tests.
  • Participates in development of analytical methods. Leads interactions with Quality Control and other Operations groups to understand and improve existing analytical methods opportunities in a highly automated environment.
  • Cell Culture: Participates in design and development of SUT cell culture equipment / processes to support the production and manufacturing of recombinant proteins (including mAbs) under varying levels of direction, including, but not limited to cell culture scaleup, media development, harvest (recovery) process development, process range finding, and statistical analysis of data. Aids in the development of SUT bioreactor process development, and SUT cell culture clarification for new product testing and implementation for Thermo Fisher and PSG.
  • Purification: Participates in the understanding of the development of recombinant protein purification processes, including chromatography process, ultrafiltration / diafiltration, nanofiltration, process characterization and optimization, process scale up, scale down model qualification, viral clearance validation. Able to participate in the discussions of the development of transfer of purification processes which can be scaled up for protein production.
  • Travel: Located in St Louis at Patheon BCC site, able to travel up to 25 % as required.


How will you get here?

Education
  • Bachelor's degree or Master’s degree or PhD in biology, chemistry, biochemistry, chemical engineering, or a related field.
  • B.S. in Chem Eng, Biochemistry, Biology or related field with 8 yrs, Masters with 6 yrs, or Ph.D. with 3 yrs
    Equivalency:
    Equivalent combinations of education, training, and relevant work experience may be considered.

Experience
  • Advanced and deep knowledge of varied aspects or a specialized aspect of Single Use Technologies and working knowledge of principles and concepts in other relevant disciplines.
  • Strong knowledge of general cGLP procedures and those specific to discipline.
  • Strong knowledge of GMP/ GLP regulations in cGMP/ cGLP manufacturing environment.
  • Demonstrated leadership skills. Excellent problem solving and critical thinking skills

Knowledge, Skills, Abilities
  • Excellent writing, communication and presentation skills. Strong MS Excel, PowerPoint and Word skills. Microsoft Project skills preferred.
  • Excellent organization and planning skills. Strong attention to detail and ability to adhere to standards procedures. Ability to design complex studies based on the deliverables. Ability to analyze and summarize complex scientific data.
  • Ability to author reports, procedures, and other documents. Ability to function in a rapidly changing cross company matrixed environment.
  • Strong attention to detail and ability to adhere to standards procedures. Ability to read, analyze, and interpret general business periodicals, professional journals, technical procedures, or governmental regulations. Ability to make and communicate complex decisions.
  • Ability to apply complex mathematical concepts to physical problems in areas. Ability to apply rigorous attention to detail when executing experimental protocols. Ability to perform all process steps and to guide lab personnel on the operation of all process steps.
  • Ability to speak effectively before groups of customers and employees. Ability to apply complex mathematical concepts to physical problems in areas such as heat and mass transport. Ability to lead and mentor less experienced staff.



At Thermo Fisher Scientific, each one of our 70,000 extraordinary minds has a unique story to tell. Join us and contribute to our singular mission—enabling our customers to make the world healthier, cleaner and safer.

Apply today! http://jobs.thermofisher.com

Thermo Fisher Scientific is an EEO/Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status.




If you are an individual with a disability who requires reasonable accommodation to complete any part of our application process, click here for further assistance.

Thermo Fisher Scientific is an EEO/Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status.

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Senior Engineer Systems Design-Cell Culture

Patheon
Missouri City, TX 77489

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