3 days old


Pacific Biosciences
Menlo Park, CA 94025
Pacific Biosciences is looking for a highly motivated, organized, and team-oriented Scientist to develop protein based products for the SMRT Sequencing system.

This position will be part of development and manufacturing team to assist commercialization of cutting edge third generation sequencing technology.  The successful candidate will be required to interact with R&D team, develop and scale up protein manufacturing processes.  The candidate will be also responsible for production of recombinant proteins conforming product specifications. 

The ideal candidate would have:

  • Broad knowledge in chemistry, biochemistry, protein chemistry, enzymology and molecular biology.

  • Strong experience in developing manufacture processes for recombinant proteins, preferably from bacterial expression system.

  • Experience in manufacturing of protein products under ISO environment.

  • Experience in analytical tools used for characterization of enzymes.

  • Strong collaborative and team work attributes.

  • Solid skills in troubleshooting and developing corrective solutions.

  • Willing to be hands-on, getting into lab to execute to plan.

  • A successful track record of developing and manufacturing protein based commercial products.


  • Design and execute purification strategies leading to effective scaled-up protein manufacturing processes.

  • Design and develop analytical test methods for protein based products.

  • Conduct and complete protein production builds.

  • Establish relationship between analytical specs and product performance, as well as physical specs and manufacturing capabilities.

  • Identify opportunities for process improvements.

  • Design and execute studies to improve robustness of manufacturing process.

  • Assist RD on protein purification projects.

Position Requirements:   

  • Advanced degree in Biochemistry, Protein Chemistry, Molecular Biology or related scientific discipline.

  • MSc. with 3-5 or BSc with 5-10 year experience in development of chromatography based purification processes in Life Sciences Industry.

  • Experience in rational design of purification processes for recombinant proteins.

  • Experience working with affinity chromatography, IEX, HIC, and SEC, preferably for recombinant protein from bacterial expression system.

  • Substantial experience with automated chromatography stations such as AKTA FPLCs.

  • Experience in clean room operations.

  • Experience in analytical test methods for protein characterization including HPLC, enzyme kinetics, protein quantification, spectrophotometer, spectrofluorometer, SDS-PAGE. 

  • Experience in bacterial fermentation with bioreactor would be a plus.

  • Excellent troubleshooting skills.

  • Effective verbal and written communication skills, team work, and ability to take initiative in a fast pace environment.


All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, national origin, protected veteran status, or on the basis of disability, gender identity, and sexual orientation.


Posted: 2019-05-19 Expires: 2019-06-18

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Pacific Biosciences
Menlo Park, CA 94025

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