Maybe one of your new year's resolutions is to quit your job. Congratulations! Just make sure you do it right.
First, of course, be certain that your new job is absolutely positively nailed down. Don't be left out in the cold without a paycheck! After that, the quitting process can be broken down into three stages.
Number one, before you give notice, get your work up to date and organized. Remove personal stuff from your company computer. Clear your browser cache, remove passwords, delete personal email. Do you have any vacation or comp time coming? Know this now so you can make sure to get compensated.
Number two, when you give notice tell your boss in private and before you tell anyone else. Know in advance what you're going to say and how. Display some regret--no one likes to be rejected, not even bosses. This is the moment that your boss ceases to be your boss and becomes part of your network (in fact, now is a good time to ask for a letter of recommendation, to add to your portfolio).
